Tuloso-Midway's quest to return to the Region IV-4A championship begins in their own backyard Friday.
The Cherokees, the District 31-4A champion and winners of their last 14 games, open the state playoffs at home Friday night with a one-game playoff against Mission Veterans Memorial. Game time is 7 p.m.
The Cherokees are 21-2 for the season.
Tuloso-Midway is led by ace pitcher Emily Brittain, who on Monday, signed a national letter of intent to play at St. Mary's University in San Antonio.
Brittain is 21-2 this season.
The Cherokees are also loaded offensively and have outscored their opposition this season, 200-20.
Tuloso-Midway lost to Medina Valley, 1-0, in the regional finals last season.
The winner of the Tuloso-Midway and Mission Veterans game will move on to the area round of the playoffs to face either Pleasanton or Port Lavaca Calhoun next week.
In Class 3A, the Robstown Lady Cotton Pickers also begin the state playoffs Friday. They are facing Rio Hondo in a best-of-three series.
The series begins with Game 1 in Rio Hondo at 7:30 p.m. Friday.
Game 2 is in Robstown at 3 p.m. Saturday. If needed, Game 3 will follow.